Ugh. The shit those animals are gonna have to deal with…
They’re not dire wolves. They are not, in any meaningful way, A. dirus. They’re gray wolves with 14 genes modified in 20 locations. The wolf genome has something like 19,000 genes, which means they’ve changed less than 0.07% of the genome of the gray wolf.
Aenocyon dirus and Canis lupus share 99.5% identical DNA according to Colossal themselves. That means these animals aren’t even 1/5 of the way to being A. dirus. Colossal’s claiming they ‘basically’ have the morphology, therefore they’re the species, but even that’s bullshit. That’s like claiming that putting a fiberglass body shell on your Volkswagen makes it a real Alfa Romeo Spyder.
I get why they did this: It’s a lot faster as a proof of concept to show investors so they can be like ‘yes, this is possible’ when you’re working with canines that take 2 months to gestate instead of pachyderms that need two years. (And by all accounts, including the Humane Society who oversaw their animal husbandry, they are doing everything the right way as far as the surrogate mothers are concerned, including planned c-sections. So no shade on their treatment of animals, either.)
I even get why they made the announcement now: With grant money drying up, a lot of research labs out there are going to be looking for the private investments that Colossal’s been living on.
So, yeah, I get it… but it’s a lie, and I don’t like it. Not one little bit. Talk about it as proof of concept: the technique they’re using for getting stem cells to reprogram from blood instead of needing painful and invasive biopsies is, itself, a huge leap forward, and something every medical lab should be cheering on. It opens the door to much more accessible research lines for things like using your own edited stem cells to grow a bone marrow graft for treating sickle-cell anemia, and hundreds of similar applications.
Just that should be massive. But they wanted to go for the splashy headline, and they deserve every single bit of pushback they’re getting.